Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10
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چکیده
منابع مشابه
Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake
BACKGROUND CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6 mediated nicotine metabolism, and total nicotine clearance, and has been associated with differences in numerous smoking behaviors....
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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important tobacco-specific nitrosamine (TSNA) in the etiology of tobacco-related cancers, and N-glucuronidation is an important mechanism of NNAL detoxification. In the present study, an analysis of the UDP-glucuronosyltransferases (UGTs) responsible for the N-glucuronidation of the TSNAs N'-nitrosonornicotine, N'-nitrosoanabasine, and ...
متن کاملUGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
BACKGROUND Identifying sources of variation in the nicotine and nitrosamine metabolic inactivation pathways is important to understanding the relationship between smoking and cancer risk. Numerous UGT1A and UGT2B enzymes are implicated in nicotine and nitrosamine metabolism in vitro; however, little is known about their roles in vivo. METHODS Within UGT1A1, UGT1A4, UGT1A9, UGT2B7, UGT2B10, an...
متن کاملGlucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
Nicotine, the major addicting agent in tobacco and tobacco smoke, undergoes a complex metabolic pathway, with approximately 22% of nicotine urinary metabolites in the form of phase II N-glucuronidated compounds. Recent studies have shown that UGT2B10 is a major enzyme involved in the N-glucuronidation of several tobacco-specific nitrosamines. In the present study, microsomes of UGT2B10-overexpr...
متن کاملcuronidation Genotypes and Nicotine Metabolic notypes: Importance of Functional UGT2B10 and R 2B17 Polymorphisms
ownloade curonidation is an important pathway in the metabolism of nicotine, with previous studies suggesting 22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studve suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine onidation with polymorphisms in both enzymes shown to significantly alter the levels o...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2012
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32834ff3a5